NMR Spectroscopy of Tethered Biological Assemblies

Tethered assemblies - systems where a small molecule is either transiently or covalently bound to a macromolecule - occur repeatedly in nature. Examples include enzyme-substrate complexes, proteins or small intercalants bound to DNA, and substrates bound to receptors. Such tethered assemblies can also involve hybrid systems composed of synthetic polymers and bioactive substances, such as those used for controlled release of drugs.