Remote Monitoring of Freely-Dispersible Microparticle Biosensors Using Optical Coherence Tomography

Submicron-scale monitoring of microparticle biosensors embedded in 3D tissue-mimics was achieved using spectroscopic OCT. Glucose-responsive microparticles exposed to continuous flow were spatiotemporally-tracked, and modeled as optical cavities to quantify volumetric changes from fluctuating concentration levels.