Tethered Biological Systems: Results from NMR Spectroscopy

By "tethered" biological systems, we mean assemblies in which two or more molecules are either covalently or transiently joined together for the purpose of biological action. Tethered systems are a recurring theme in biophysics; examples include enzyme - substrate complexes, DNA - protein interactions, receptor - ligand binding, and antigen - antibody recognition. NMR spectroscopy is exceptionally well-suited to address key questions regarding both site - site recognition and chain folding in tethered biological assemblies.